Development of novel echogenic-imageable thermosensitive liposome for optimizing tumor drug distribution using ultrasound guided HIFU
نویسندگان
چکیده
Background/introduction A major challenge in HIFU mediated Image Guided Drug Delivery (IGDD) is developing accurate means to implement real-time drug delivery control, and to optimize intratumoral drug distribution. To facilitate clinical translation, objectives of this study were to: 1) develop echogenic E-LTSL, a low temperature sensitive liposome co-loaded with an US contrast agent (Perfluoropentane, PFP) and doxorubicin, 2) determine stability of contrast agent encapsulation and characterize doxorubicin release from E-LTSL and 3) investigate the ability of E-LTSL to report on realtime doxorubicin distribution with Ultrasound (US)-guided hyperthermia.
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2015